Modification of <i>KCNH2</i>-Encoded Cardiac Potassium Channels by KCNE1 Polymorphism
نویسندگان
چکیده
منابع مشابه
Modification of KCNH2-encoded cardiac potassium channels by KCNE1 polymorphism.
fects. Co-expression of KCNE1 (D76N) or KCNE1 (D85N) increases the susceptibility to clarithromycin, a macrolide antibiotic, lowering the IC50 to 1/3–2/3, whereas that of KCNE1 (A8V) decreases the susceptibility, doubling the IC50.1 Coexpression of KCNE1 (A8V), KCNE1 (D76N), or KCNE1 (D85N) increases the susceptibility to cisapride, a gastric prokinetic drug, lowering the IC50 to 1/2.1 Co-expre...
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Cardiac K+ channels are membrane-spanning proteins that allow the passive movement of K+ ions across the cell membrane along its electrochemical gradient. They regulate the resting membrane potential, the frequency of pacemaker cells and the shape and duration of the cardiac action potential. Additionally, they have been recognized as potential targets for the actions of neurotransmitters and h...
متن کاملTitle Pharmacology of Cardiac Potassium Channels
Cardiac K channels are cardiomyocyte membrane proteins that regulate K ion flow across the cell membrane on the electrochemical gradient, and determine the resting membrane potential and the cardiac action potential morphology and duration. Several K channels have been well studied in the human heart. They include the transient outward K current Ito1, the ultra-rapidly delayed rectifier current...
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ژورنال
عنوان ژورنال: Circulation Journal
سال: 2014
ISSN: 1346-9843,1347-4820
DOI: 10.1253/circj.cj-14-0654